Department: DPB – Plant Biology
Location: Palo Alto, CA
A bioinformatics/computational biology postdoctoral research position is available immediately in the laboratory of Dr. Sue Rhee at Carnegie Institution’s Plant Biology Dept (Palo Alto, CA). The main goal of the project is to develop an algorithm to predict causal genes from QTL regions in plants, particularly in the model C4 grass Setaria. This project has opportunities to use genomics and functional genomics data in plants, both publicly available and newly generated in our consortium, to build an algorithm that can accelerate the discovery of genes that are responsible for phenotypic variation in metabolic and developmental traits in response to drought and high-density planting in Setaria. This is a collaborative project among several pioneering labs in plant physiology, genetics, engineering, and computational biology (www.foxmillet.org).
Qualifications: Qualified candidates must have: 1) a Ph.D. or equivalent in Computer Science, Biology, Bioinformatics, Mathematics, Engineering or related field; 2) expertise or fluency in large-scale data analysis, statistics, genomics, machine learning, and/or related field; and 3) proficient in programming. Candidates with experience in developing machine learning algorithms and/or trained in quantitative genetics, evolutionary biology, or population genetics are especially encouraged to apply. The successful candidate should have a demonstrated ability for independent and critical thinking, ability and initiative to learn new things, excellent communication and teamwork skills and passion for biological research.
Responsibilities: The successful candidate will develop a computational method/algorithm to rationally prioritize causal genes underlying QTLs from GWAS and QTL mapping studies using functional genomics data such as RNAseq, sequence
polymorphisms, evolutionary signatures, and functional annotations. The candidate will also work with scientists in the consortium who are generating the mapping and functional genomics data as well who will test the predicted causal genes using state of the art molecular biology, genetics, plant physiology, and genome editing tools.
Carnegie Institution for Science (http://carnegiescience.edu/) is a private, nonprofit organization for scientific discovery founded by Andrew Carnegie in 1902. He intended the institution to be home to exceptional individuals with imagination, intelligence and enjoyment capable of creating and expanding the cutting edge of their fields. Today, Carnegie scientists work in six scientific departments on the West and East Coasts. The Department of Plant Biology engages in basic research on the mechanisms involved in the growth and development of plants and algae. The Department of Plant Biology is located on the campus of Stanford University. Carnegie is an equal opportunity employer.