Department: EMB – Embryology
Location: Baltimore, MD
The Zheng Lab at the Carnegie Institution’s Department of Embryology seeks ambitious postdoctoral fellows interested in understanding the role of lamins in mouse development. The Zheng lab has developed mouse models that allow the study of individual and different combinations of the three lamin genes using germline or conditional lamin knockout. The lab also developed mouse embryonic stem cells lacking all or different combinations of lamins. By employing a wide range of genomic tools and cell biological approaches, the lab has observed a number of interesting phenotypes in different lamin knockout combinations. We seek a postdoctoral fellow with skills in analyzing mouse early embryos, ES cell derivation, and the use of ES cells to study differentiation.
- Kim Y…Zheng Y (2011). Mouse ES cells do not need any lamins but proper organogenesis requires lamin-Bs. Science 334:1706-1710.
- Jia J…Zheng Y (2012). Regulation of pluripotency and self-renewal of ES cells through epigenetic threshold modulation and mRNA pruning. Cell 151:576–589.
- Chen H, Chen X, and Zheng Y (2013). The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling. Cell Stem Cell 13:73-86.
- Chen H, Zheng X, and Zheng Y (2014). Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell 159:829-843. Zheng X…Zheng Y (2018). Lamins organize the global three-dimensional genome from the nuclear periphery. Molecular Cell DOI: https://doi.org/10.1016/j.molcel.2018.05.017 .
The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit https://emb.carnegiescience.edu/
Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status.
Please submit a copy of your resume or CV with the application. If you have further questions please reach out to Dr. Yixian Zheng, Principal Investigator.