EMB – Embryology

Postdoctoral Fellow

Department: EMB – Embryology

Salary: TBD

Location: Baltimore, MD

Overview:

The Zheng Lab at the Carnegie Institution’s Department of Embryology seeks ambitious postdoctoral fellows interested in understanding the role of lamins in mouse development. The Zheng lab has developed mouse models that allow the study of individual and different combinations of the three lamin genes using germline or conditional lamin knockout. The lab also developed mouse embryonic stem cells lacking all or different combinations of lamins. By employing a wide range of genomic tools and cell biological approaches, the lab has observed a number of interesting phenotypes in different lamin knockout combinations. We seek a postdoctoral fellow with skills in analyzing mouse early embryos, ES cell derivation, and the use of ES cells to study differentiation.

Selected publications:

  1. Kim Y…Zheng Y (2011). Mouse ES cells do not need any lamins but proper organogenesis requires lamin-Bs. Science 334:1706-1710.
  1. Jia J…Zheng Y (2012). Regulation of pluripotency and self-renewal of ES cells through epigenetic threshold modulation and mRNA pruning. Cell 151:576–589.
  1. Chen H, Chen X, and Zheng Y (2013). The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling. Cell Stem Cell 13:73-86.
  2. Chen H, Zheng X, and Zheng Y (2014). Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell 159:829-843. Zheng X…Zheng Y (2018). Lamins organize the global three-dimensional genome from the nuclear periphery. Molecular Cell DOI: https://doi.org/10.1016/j.molcel.2018.05.017 .
Additional Information:

The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit https://emb.carnegiescience.edu/

Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status.

Please submit a copy of your resume or CV with the application.  If you have further questions please reach out to Dr. Yixian Zheng, Principal Investigator.

 

 

Postdoctoral Associate

Department: EMB – Embryology

Salary: NIH-NRSA Postdoctoral Stipend Scale

Location: Baltimore, MD

Job: Postdoctoral Researcher – Fan Lab

Department: Embryology

Salary: NIH-NRSA Stipend Scale

Location: Baltimore, MD

Job Summary:

A postdoctoral position to study muscle regeneration and muscular dystrophy using the mouse model is available in the laboratory of Dr. Fan at the Carnegie Institution for Science, Department of Embryology, in Baltimore, MD.

The research objective is to understand normal and pathological muscle biology from the stem cell perspective.  The position requires a highly-motivated applicant with a strong interest in stem cell biology. The position involves conducting research using mouse as a model organism. Applicants are expected to have research background in molecular biology, cell biology, and genetics. The research approach is to use up-to-date methods and develop new techniques and tools to study muscle stem cell quiescence, activation, differentiation, in normal, aging and diseased conditions.

The Carnegie Department of Embryology follows the current NIH-NRSA postdoctoral stipend scale and our postdoctoral benefit package includes health care, sick leave, annual leave, parental leave, life insurance, and paid holidays.

To learn more about the Fan Lab please click here.

Qualifications:

An ideal candidate will be creative, industrious, have excellent communication skills, and enjoy working independently as well as collaboratively. A Ph.D. in a related field and fluency in spoken and written English is required for the position.

To apply:

A CV, statement of research interest, and contact information for three references are required to apply.

Additional information:

The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit https://emb.carnegiescience.edu/

Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status.

 

Research Scientist

Department: EMB – Embryology

Salary: Based on experience

Location: Baltimore, MD

Overview:

The Carnegie Institution for Science is seeking a skilled Research Scientist to join the Fan Lab at the Department of Embryology located in Baltimore, MD. Please click here to learn more about the Fan Lab.

Essential Functions:

  • The candidate will be responsible for the design and implementation of one or more independent projects. With minimal supervision, determine most suitable methods to be used in independent research projects; perform scientific experiments and procedures; interpret results and determine consistency with experimental goals; review literature; interpret subsequent data. Often explores new areas and seeks opportunities to apply new knowledge to work. Train and manage lab technician to support research projects. The exercise of judgement is a prime factor in the performance of duties. Incumbent is vested with final authority to make decisions within the limits of established policies and practices.

Principle Responsibilities:

  • Independently perform laboratory research activities related to assigned project
  • Analyze data, formulate conclusions and create appropriate statistical presentation, including graphs and charts, and prepare and present written or oral progress reports regarding studies
  • Administer day-to-day laboratory operations including monitoring budget, ensuring quality control and safety compliance, development policies and procedures and ordering supplies
  • Maintain proper operation of research equipment, ensuring proper operation records, cleaning, ordering of required components and resolving technical issues
  • Actively contributes to laboratory meetings and planning sessions
  • Prepare written reports and manuscripts for submission to peer-reviewed journals for publication
  • Train new students, postdoctoral researchers, and technical personnel in a variety of laboratory techniques
  • Manage lab technician to support the research of students and postdoctoral researchers, as well as fulfill general laboratory needs
  • Work efficiently and cooperatively with a team of researchers in support of lab goals and projects

Qualifications:

  • PhD degree in a relevant field and one or more positive letters of reference from scientist(s) familiar with the candidate’s research and work ethic
  • Experience in the development and use of mouse models.
  • Able to critically review information and understand new concepts and techniques with minimal assistance
  • Strong organizational and computer skills, meticulous attention to detail
  • Excellent verbal and written communication skills
  • Enthusiasm for developing new skills and expertise
  • Ability to work independently and effectively

Physical Requirements:

  • Occasionally lifts and /or carries objects weighing up to 25 pounds
  • Occasionally stoops and bends
  • Occasionally reaches and grasps with arms and hands above head
  • Work is performed in a normal laboratory environment where there are relatively few physical discomforts due to dust, dirt, noise, or similar
  • Work involves possible exposure to malodorous vapors, low-dose radiation, contamination by toxic chemical and acids and presence of carcinogenic substances

Additional Information:

The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit https://emb.carnegiescience.edu/

Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status.

Postdoctoral Fellow-Kostova Lab

Department: EMB – Embryology

Salary: TBD

Location: Baltimore, MD

Overview: A postdoctoral position is available in the laboratory of Dr. Kamena Kostova (https://kostovalab.org/) at the Carnegie Institution for Science, Department of Embryology in Baltimore, MD. We are investigating the fundamental question of how cells respond when their ribosomes break down. The ribosome is one the most complex and long-lived molecular machines in the cell and the presence of functional ribosomes is essential to live. Ribosome damage has been recently linked to complex human diseases, such as cancer and neurodegeneration. We use cutting-edge technology, such as CRISPR-Cas9-mediated genome editing and genome scale screens, to model and map the molecular pathways that ensure ribosome integrity in mammalian cell lines and zebrafish.

Qualifications: An ideal candidate will be creative, industrious, have excellent communication skills, and enjoy working independently as well as collaboratively. A Ph.D. in a related field and fluency in spoken and written English is required for the position.

To apply: Please send a curriculum vitae, statement of research interest, and contact information for three references to kostova@carnegiescience.edu.

Additional Information:

The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit http://emb.carnegiescience.edu/

Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability.